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Abstract #4782

Free-Water Elimination (FWE) reduces partial volume effects from cerebrospinal fluid in DTI of the human spinal cord

Alma Blombäck1, Maria Ljungberg1,2, Hampus Olsson3, and Kerstin Lagerstrand1,2
1Department of Medical Radiation Sciences, Institute of Clinical sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 2Dept of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden, 3Philips, Gothenburg, Sweden

Synopsis

Keywords: DWI/DTI/DKI, Artifacts, Free-water elimination, partial volume effect

Motivation: Diffusion tensor imaging in the spinal cord is compromised by partial volume effects from surrounding cerebrospinal fluid. Free-water elimination shows promise of partial volume effect reduction in the brain but has never been tested on the human spinal cord.

Goal(s): Determine the feasibility of free-water elimination for diffusion tensor imaging of the human spinal cord.

Approach: The free-water elimiation correction was tested on both simulated data and in vivo on a healthy volunteer.

Results: Free water elimination produced realistic parameter maps and deomstrated reduced partial volume effects in both simulated and in vivo data.

Impact: Findings display reduced partial volume effects in diffusion tensor imaging of spinal cord with the use of free-water elimination. Potentially facilitating more accurate assessment of microstructural changes and surveillance of patients with spinal cord affection.

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