Meeting Banner
Abstract #4784

Architectural Disruption Signature: Region-specific MRI Biomarkers in Cuprizone-induced Demyelination for Alzheimer’s Disease

Zhuoheng Liu1, Pratham Eddula2, Mubashir Jafry3, Jie Chen1, and Nian Wang1,4,5
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2University of North Texas, Denton, TX, United States, 3Missouri Southern State University, Joplin, MO, United States, 4Department of Biomedical Engineering, UT Southwestern Medical Center, Dallas, TX, United States, 5Peter O'Donnell Jr. Brain Institude, UT Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: Microstructure, Alzheimer's Disease

Motivation: Demyelination is a key aspect of Alzheimer’s disease, with cuprizone mouse models enabling region-specific pathological research.

Goal(s): To characterize microstructural differences between SAA and cuprizone-treated SAA mice in isocortex and hippocampal regions using multi-modal MRI.

Approach: Analyzed 7 cuprizone-treated vs 7 control male mice using: DWI for DTI, DKI, NODDI metrics across 684 regions, T2* mapping and QSM analysis.

Results: Multi-modal MRI analyses revealed significant microstructural alterations in cuprizone-treated mice, including changes in diffusion parameters, and tissue composition across isocortex and hippocampal regions.

Impact: This comprehensive multi-modal MRI analysis provides insight into region-specific pathological changes in the cuprizone model, particularly in isocortex and hippocampal areas. These findings enhance our understanding of demyelination processes and could guide the development of targeted therapeutic strategies for AD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords