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Abstract #4789

Measuring Perfusion in normal and pathological placentas using an advanced IVIM method.

Nahla M H Elsaid1, Hemant D Tagare2,3,4, Julius S Ngwa1, Kushal Kapse1, Catherine Limperopoulos1, and Nickie Andescavage1
1Division of Diagnostic Imaging & Radiology, Children’s National Health System, Washington, DC, United States, 2Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 3Biomedical Engineering, Yale University, New Haven, CT, United States, 4Statistics and Data Science, Yale University, New Haven, CT, United States

Synopsis

Keywords: IVIM, Prenatal

Motivation: Placental health is critical for maternal-fetal wellness, and placental vascular malperfusion detected after delivery is associated with fetal growth restriction (FGR).

Goal(s): To better understand and analyze the placenta's health, we developed a novel analysis method for IVIM that is clinically feasible and can calculate more accurate IVIM parameter maps.

Approach: The method utilizes a mixture prior to enhance the estimation of each voxel's IVIM parameters by drawing statistical power from all voxels.

Results: Our method calculates IVIM parameter maps with a plausible range of estimated f and D*. It also improves prenatal discrimination between healthy placentas and those with FGR.

Impact: To better understand and analyze in-vivo placental perfusion, we developed a novel method based on mixture-prior for intravoxel incoherent motion (IVIM). It shows an improved ability to distinguish between control and growth-restricted placentas.

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Keywords