Abstract #4796

DTI-ALPS mapping: A Novel Method for Analyzing the Glymphatic System in the Brain

Xiqian Zhang^1,2, Xiang Fan³, Keyan Yu³, Qian Li¹, Xuanle Li^1,4, Yulong Qi³, Lele Chen³, Zhuonan Wei³, Gaigai Lu³, Hui Chen³, Lin Hu³, Guanxun Cheng³, and Na Zhang^1,2,5,6

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²University of Chinese Academy of Sciences, Beijing, China, ³Department of Medical Imaging, Peking University Shenzhen Hospital, Shenzhen, China, ⁴Institute of Data Science, City University of Macau, Macau, China, ⁵Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, Shenzhen, China, ⁶United Imaging Research Institute of Innovative Medical Equipment, Shenzhen, China

Synopsis

Keywords: DWI/DTI/DKI, Alzheimer's Disease, DTI-ALPS

Motivation: A voxel-based mapping method could display the entire cerebral white-matter ALPS index, allowing full-scale analysis of ALPS index.

Goal(s): To develop a novel method for intuitively and comprehensively assessing glymphatic system activity and tracking full-scale ALPS changes along the dementia continuum.

Approach: Proposed a voxel-based DTI-ALPS mapping method, segmenting the entire cerebral white-matter fibers into 30 regions for group comparison. Validated against conventional ROI-based methods for reliability.

Results: The voxel-based DTI-ALPS mapping identified significant inter-group differences in mean ALPS values across multiple regions. Its consistency with the conventional method supports its reliability, while offering a more detailed view of ALPS variations.

Impact: This study represents a pioneering effort by introducing a white matter DTI-ALPS mapping technique. This innovative approach significantly enhances the detection of differences associated with cognitive decline and offers a more comprehensive perspective for advancing our understanding of neurodegenerative processes.

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