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Abstract #4801

Does the packed impermeable sphere model explain time-dependent diffusion of brain tumors measured with clinical scanners?

Kouhei Kamiya1, Masataka Mikai2, Yutaka Fuchinoue2, Chie Nakada2, Katsutoshi Murata3, Thorsten Feiweier4, Masaaki Hori1, and Nobuo Sugo2
1Department of Radiology, Faculty of Medicine, Toho University, Tokyo, Japan, 2Department of Neurosurgery, Faculty of Medicine, Toho University, Tokyo, Japan, 3Siemens Healthcare K.K., Tokyo, Japan, 4Siemens Healthineers AG, Erlangen, Germany

Synopsis

Keywords: Microstructure, Diffusion Modeling, Time-dependent diffusion

Motivation: While biophysical models typically represent tumor as packed impermeable spheres, it is nontrivial whether such picture is appropriate within the range of diffusion time available with clinical scanner.

Goal(s): We aimed to identify the power-law scaling that describes the time-dependent diffusion of brain tumors measured with a clinical scanner.

Approach: We measured the diffusion coefficient of seventy-six brain tumors at diffusion times between 35-300 ms using a stimulated-echo based sequence.

Results: The diffusion coefficient of meningiomas and metastatic tumors decreased with diffusion time slower than the prediction from the packed impermeable sphere model.

Impact: The tissue features dominating diffusion time dependence of tumors may vary depending on histology and may possibly deviate from the packed impermeable sphere model.

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