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Abstract #4806

Designing a clinical diffusion MRI acquisition to measure white matter damage in paediatric brain tumour patients

Emily Drabek-Maunder1,2,3, Manuela Cerbone1,2, Kshitij Mankad2, Kristian Aquilina2, Jamie A. Dean3, Andy Nisbet3, and Christopher A. Clark1,2
1UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom, 2Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 3Medical Physics & Biomedical Engineering, University College London, London, United Kingdom

Synopsis

Keywords: Diffusion Acquisition, DWI/DTI/DKI

Motivation: Children with brain tumours often face neurocognitive deficits. Determining if white matter injury is due to the tumour or treatment could facilitate tailoring therapies.

Goal(s): To assess if shorter diffusion MRI protocols can reliably detect white matter abnormalities, allowing for faster, clinically feasible scanning.

Approach: White matter abnormalities were evaluated using tract-based spatial statistics across 3 diffusion MRI acquisitions, comparing patients to age- and sex-matched healthy controls with a one-against-many analysis.

Results: Shorter diffusion MRI acquisitions were nearly as effective as longer ones in detecting white matter abnormalities, reducing scan times from approximately 8 minutes to 2 minutes.

Impact: This study demonstrates that shorter diffusion MRI protocols can reliably detect white matter abnormalities, facilitating the integration of diffusion MRI into clinical workflows. This could support personalised treatment planning in paediatric brain tumour care and improve patient outcomes.

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Keywords