Meeting Banner
Abstract #4817

Effects of varying diffusion mixing time in ex-vivo cardiac DTI: a comparison of spin echo and stimulated echo sequences

Camila Munoz1,2, Alberto Di Biase1,2, Karl P Kunze3, Karen P McCarthy4, Dudley J Pennell1,2, Pedro F Ferreira1,2, Andrew D Scott1,2, and Sonia Nielles-Vallespin1,2
1National Heart and Lung Institute, Imperial College London, London, United Kingdom, 2CMR Unit, Royal Brompton and Harefield Hospitals, London, United Kingdom, 3MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 4Cardiac Morphology Unit, Royal Brompton and Harefield Hospitals, London, United Kingdom

Synopsis

Keywords: Microstructure, Diffusion Analysis and Visualization, Cardiac microstructure

Motivation: Ex-vivo cardiac diffusion MR has improved our understanding of the heart microstructure, depicting in detail the primary helical arrangement of cardiomyocytes in the myocardium. However, accurate depiction of the secondary laminar arrangement of cardiomyocytes (sheetlets) remains challenging.

Goal(s): To assess the ability of spin echo (SE) and stimulated echo (STEAM) MR diffusion to characterize sheetlet orientation ex vivo.

Approach: Data was acquired with both sequences and varying diffusion mixing times. Voxel-wise diffusion tensor maps were obtained for each dataset.

Results: SE and STEAM provide a similar depiction of the primary and secondary cardiomyocyte structures at moderate spatial resolution, with SE offering higher SNR.

Impact: High SNR spin-echo based ex-vivo cardiac MR diffusion can provide an accurate characterization of cardiac microstructure and enable high resolution depiction of sheetlet organization in the heart.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords