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Abstract #4825

Towards a high-resolution Neuro 31P-MRS at 3T

Qiurong Yu1,2, Naying He1, Xiaoyong Zhang1,2, Jinyuan Weng3, Peng Wu3, Yixin Zhou2, Yuxiang Teng2, Ruokun Li1,2, and Fuhua Yan1,2
1Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Philips Healthcare, Shanghai, China

Synopsis

Keywords: Data Processing, Neuro, 3T Phosphorous MRS, protocol optimization, CRLB simulation

Motivation: For 31P-MRSI, it hard to keep a good balance between the scan time, scan resolution and accurate qualification of different metabolites at 3T.

Goal(s): To get a high-resolution 31P-MRSI protocol with reasonable scan time. Also evaluate the influence of NSAs on different metabolites.

Approach: Five healthy volunteers underwent high-resolution 31P scanning with 8 number of signal averages. The Cramer-Rao Lower Bounds (CRLBs) for different NSAs were estimated for different metabolites.

Results: Recommended NSAs for different Metabolites of concern could be obtained with CRLB. In our case, NSA of 2 may be suitable for most of the metabolites with a reasonable scan time.

Impact: This study optimized a high-resolution neuro 31P protocol via CRLB simulation. Suggested NSA numbers were provided for different metabolites and different brain regions.

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