Meeting Banner
Abstract #4845

Safety and efficacy of MR-guided low intensity transcranial ultrasound stimulation for depression

Xin Cai1, Wei Sun1, Xiaodan Zheng1, Ningding Ding1, Yang Liu2, De Meng3, Bo Yuan1, and Xiaojing Long2,4
1Shenzhen Samii Medical Center, Shenzhen, China, 2Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 3GreenValley BrainTech (Shenzhen) Medical Technology Co. Ltd., Shenzhen, China, 4The Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, Shenzhen, China

Synopsis

Keywords: MR-Guided Focused Ultrasound, Focused Ultrasound

Motivation: Transcranial focused ultrasound stimulation (TUS) which offers a higher resolution potentially allows for more targeted neuromodulation.

Goal(s): This study aimed to explore the potential of low-intensity TUS to precisely target the brain under MR guidance for safe and effective treatment of depression.

Approach: A clinical study was conducted in 20 patients, with neuropsychological assessments and functional MRI scans. All patients underwent TUS on BA 46 of the left dorsolateral prefrontal cortex for 10 days.

Results: Results demonstrated that TUS significantly improved depression, anxiety scores, as well as sleep quality, and mood improvement was closely related to functional connectivity changes.

Impact: This study introduces a non-invasive MR-guided ultrasound therapy that effectively alleviates depression symptoms, marking a significant step forward in mental health treatment.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords