Meeting Banner
Abstract #4855

Neurovascular decoupling of the frontoparietal cortex–putamen–cerebellum network in type 2 diabetes patients with abnormal eating patterns

Ying Yu1, Bo Hu1, and Guang-Bin Cui Cui1
1Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi’an, China

Synopsis

Keywords: Gray Matter, biomarkers, eating behavior disorder

Motivation: High rates of dropout and binge eating triggered by restrictive diet limit the effectiveness of dietary interventions in type 2 diabetes mellitus(T2DM).

Goal(s): To investigate the dietary behavior characteristics of Chinese T2DM patients, the related network, the potential central underpinnings and the imaging biomarkers.

Approach: fMRI and Event-based model were used to screen the suspicious network , to explore the dynamic temporal and neurovascular coupling properties of it, and to estimate the timeline of neuropathologic and clinical changes during T2DM progression.

Results: Frontoparietal cortex-putamen-cerebellum network was the suspicious network for T2DM-related abnormal eating patterns. Neurovascular decoupling of Putamen_R occurred early during T2DM progression.

Impact: These findings support the concept that hyperactive reward circuit and cerebellum play critical role in the eating disorders which leads to further deterioration of type 2 diabetes, and advance understanding of the dietary behavior in type 2 diabetes.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords