Keywords: Gray Matter, biomarkers, eating behavior disorder
Motivation: High rates of dropout and binge eating triggered by restrictive diet limit the effectiveness of dietary interventions in type 2 diabetes mellitus(T2DM).
Goal(s): To investigate the dietary behavior characteristics of Chinese T2DM patients, the related network, the potential central underpinnings and the imaging biomarkers.
Approach: fMRI and Event-based model were used to screen the suspicious network , to explore the dynamic temporal and neurovascular coupling properties of it, and to estimate the timeline of neuropathologic and clinical changes during T2DM progression.
Results: Frontoparietal cortex-putamen-cerebellum network was the suspicious network for T2DM-related abnormal eating patterns. Neurovascular decoupling of Putamen_R occurred early during T2DM progression.
Impact: These findings support the concept that hyperactive reward circuit and cerebellum play critical role in the eating disorders which leads to further deterioration of type 2 diabetes, and advance understanding of the dietary behavior in type 2 diabetes.
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