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Abstract #4859

Spatiotemporal changes of cortical cytoarchitectural complexity across brain regions and between genders during infancy

Ziqin Zhang1,2, Ruolin Li1,2, Cheng En Lee1, Tianjia Zhu1,2, Kay Sindabizera1, Runjia Lin1,3, Sovesh Mohapatra1,2, Minhui Ouyang1,4, and Hao Huang1,4
1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Department of Bioenginnering, University of Pennsylvania, Philadelphia, PA, United States, 3School of Software, Dalian University of Technology, Dalian, China, 4Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Gray Matter, Normal development, infant, cortical microstructure, early development, diffusion MRI

Motivation: Human infancy is characterized by the fastest brain changes. However, little is known about the spatiotemporal dynamics of cortical cytoarchitectural complexity.

Goal(s): To reveal spatiotemporal changes of cortical cytoarchitectural complexity across infant brain regions and between genders.

Approach: We measured cortical cytoarchitectural maturation during infancy using diffusion kurtosis-derived mean kurtosis maps from multi-shell infant diffusion MRI of the highest resolution available to date and captured both shared and unique cytoarchitectural change patterns employing generalized additive models.

Results: The results revealed both common growth trends across brain regions and between genders as well as unique regional and gender differences.

Impact: This study offers invaluable insight into spatiotemporal changes in cortical cytoarchitecture by leveraging cutting-edge multi-shell infant diffusion MRI with the highest resolution available to date. The cortical cytoarchitectural trendlines could serve as references for normal infant development and disorders.

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