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Abstract #4861

Multiparametric MRI Assessment of Melatonin's Effects on Neurovascular Unit of Neonatal Rats with hypoxic-ischemic brain damage

Xiaoli Wang1,2, Chenmeng Liu2,3, Zhen Li1, Yijing Wang2, Xiaozu Zhang2, Yongjun Cheng4, Peng Wu4, and Xizhen Wang1
1Medical Imaging Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China, 2School of Medical Imaging, Shandong Second Medical University, Weifang, China, 3Department of Imaging, Chengwu People's Hospital, Heze, China, 4Philips Healthcare, Shanghai, China

Synopsis

Keywords: Gray Matter, Neonatal, Hypoxic-ischemic brain damage; Multiparametric MRI; Melatonin; Neurovascular unit

Motivation: Melatonin can alleviate hypoxic-ischemic brain damage (HIBD) in newborns, but its effect on neurovascular unit (NVU) destruction in HIBD rats needs further investigation.

Goal(s): Investigate the effect of melatonin on NVU after HIBD via HIBD rat model.

Approach: MRI techniques combined with histologic methods were performed to analyze the effects of melatonin therapy on NVU in HIBD rats.

Results: MRI showed abnormal hypointensity in the cerebral cortex of the injured side in the melatonin group, and the permeability surface-area product (PS) value decreased after melatonin treatment. Various histology revealed that NVU destruction on the injured side was alleviated in the melatonin group.

Impact: Multiparametric MRI techniques combined with various histology experiments revealed that melatonin would attenuate NVU injury after HIBD. Additionally, melatonin could decrease MMP-9 expression, increase tight junction proteins, and reduce neuron damage.

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