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Abstract #4867

Evaluation of glymphatic system activity during sleep-wake states through quantitative CSF measurement using a two-pool water model

Gawon Lee1 and Se-Hong Oh1,2
1Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea, Republic of, 2Diagnostic Radiology, Diagnostic Institute, The Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: Alzheimer's Disease, Analysis/Processing, Glymphatic system, CSF

Motivation: The glymphatic system is crucial in clearing brain waste, and dysfunction has been linked to neurodegenerative diseases. Understanding this system is essential for advancing our knowledge of brain health.

Goal(s): We aim to develop a non-invasive method to assess glymphatic activity in the human brain.

Approach: We utilized a quantitative CSF measurement technique with a two-pool model and multi-echo GRASE images.

Results: Significant variations in glymphatic activity were observed across different brain regions and were found to be influenced by sleep.

Impact: Our method can potentially reveal variations in sleep-influenced glymphatic activity, allowing early diagnosis of Alzheimer's disease.

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Keywords