Meeting Banner
Abstract #4878

Association of gray-white matter junction tissue volume loss with metabolic biomarkers in patients with type 2 diabetes

Geon-Ho Jahng1, Chang-Woo Ryu1, Yunan Tian2, Soonchan Park1, and In-Kyung Jeong3
1Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, 2Medicine, Graduate School, Kyung Hee University College of Medicine, Seoul, Korea, Republic of, 3Endocrinology and Metabolism, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of

Synopsis

Keywords: Gray Matter, Brain

Motivation: Prior research has primarily focused on overall brain atrophy and white matter hyperintensities.

Goal(s): To evaluate the gray-white matter junction tissue volume (gwJTV) damage in Type 2 diabetes mellitus (T2D) patients with and without carotid plaque and its association with several metabolism-related biomarkers.

Approach: A cross-sectional study of 69 T2D patients with (36) or without (33) asymptomatic atherosclerosis was conducted by evaluating the metabolic biomarkers and the gwJTV .

Results: gwJTV was particularly sensitive to changes in these biomarkers. Higher brain tissue volumes were found in participants without plaque compared to those with plaque.

Impact: This study contributes to the field of diabetes and neuroimaging by introducing the concept of gwJTV as a new MRI measure for evaluating brain tissue integrity in T2D patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords