Keywords: Gray Matter, Parkinson's Disease, Multiple system atrophy;MRI; cortical thickness; cortex; gray matter volume.
Motivation: Multiple system atrophy (MSA) and Parkinson's disease (PD) are two frequently misdiagnosed diseases.
Goal(s): The study compared cortical thickness (CT) and gray matter volume (GMV) in MSA and PD, especially CT.
Approach: 33 MSA, 51 PD and 30 health controls underwent clinical evaluation and 3.0T magnetic resonance imaging (MRI) to collect the high-resolution three-dimensional T1- weighted MRI images. Then CT and GMV features were generated from these MRI images using the Computational Anatomy Toolbox 12 (CAT12) software.
Results: Our study revealed lower GMV of the basal ganglia and cerebellum in MSA than PD, and different patterns of cortical alterations between them.
Impact: Our results enrich the knowledge of morphometric MRI difference in MSA and PD, might become potentially useful imaging biomarkers for differential diagnosis of MSA and PD, and demonstrate the potential use of routine MRI in performing their differential diagnosis.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords