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Abstract #4884

Quantification of gray matter abnormalities in systemic lupus erythematosus patients by synthetic MRI

Kemei Deng1, Muliang Jiang1, Chengli Wu1, Wei Cui2, and Liling Long1
1The First Affiliated Hospital of Guangxi Medical University, Nanning, China, 2GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: Gray Matter, Gray Matter

Motivation: Neuropsychiatric lupus is a serious complication in systemic lupus erythematosus (SLE) patients, yet its underlying pathogenesis remains unclear.

Goal(s): To investigate gray matter (GM) microstructural alterations in SLE using synthetic MRI (SyMRI) and explore their link to anxiety and depression.

Approach: T1, T2, and PD values of GM in 52 SLE patients were acquired using SyMRI and compared to healthy controls. Associations of these values with anxiety and depression were evaluated.

Results: Altered T1 values of left inferior temporal lobe, right thalamus and left putamen, which are interconnected with limbic system, were positively correlated with anxiety in SLE patients.

Impact: The microstructural abnormalities of the limbic system may be a significant factor contributing to anxiety in patients with systemic lupus erythematosus.

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