Abstract #4887

Precise Quantitative Assessment of Hippocampal Subregional Structural Changes Associated with Cerebral Small Vessel Disease

Boyao Chen¹, Yajie Fu², Lingfei Guo³, Changhu Liang⁴, Chaofan Sui³, Yian Gao³, Na Wang³, Xinyue Zhang³, Yuanyuan Wang⁵, Zhenyu Cheng⁶, Pengcheng Liang³, Yiwen Chen³, Xinxin Huo³, and Fushuai Zhang⁶

¹Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, Jinan, China, China, ²Department of Medical Ultrasound, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China, China, ³shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Jinan, China, China, ⁴Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, China, ⁵School of Medical Imaging，Binzhou medical university,Yantai,Shandong,China, Yan, China, China, ⁶School of Medical Imaging，Binzhou medical university,Yantai,Shandong,China, Yantai, China

Synopsis

Keywords: Other Neurodegeneration, Brain, Cerebral Small Vessel Disease; Hippocampus; Dentate Gyrus; Motor Function; Cognitive Function

Motivation: This study focuses on exploring the differences in the volume of the hippocampal (Hippocampus, HP) subregions in patients with different loads of cerebral small vessel disease (CSVD).

Goal(s): To investigate the relationship between HP subregion volume changes and cognitive-motor function impairment through multivariate statistical analysis, providing a new perspective on the mechanism and prognosis of clinical symptoms of CSVD.

Approach: Prospective cohort study

Results: The volume reduction of the granular cell layer-molecular layer-dentate gyrus-head (GC-ML-DG-head) subregion of the HP was related to CSVD load, and the change in GC-ML-DG-head volume played a partial mediating role in motor function (TUG) impairment caused by CSVD.

Impact: This study provides data on HP subregion volume changes related to CSVD load, providing new evidence for the mechanism of cognitive-motor function impairment in CSVD, and offering the potential for more precise imaging markers.

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