Abstract #4890

Altered brain iron deposition patterns in iron deficiency anemia

Hannah Salcudean¹, Clio González-Zacarías^1,2, Samantha Mejia¹, Emma Carpenter³, Botian Xu^1,4, Sylvie Suriany¹, Sneha Verma¹, Anand Joshi⁵, Peter Chiarelli^6,7, Richard Leahy⁵, and John Wood^1,8

¹Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ²Ming Hsieh Department of Electrical and Computer Engineering Graduate Program, University of Southern California, Los Angeles, CA, United States, ³Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, United States, ⁴Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ⁵Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, ⁶Pediatric Neurosurgery, Children's Hospital Los Angeles, Los Angeles, CA, United States, ⁷Clinical Neurological Surgery, Keck School of Medicine of USC, Los Angeles, CA, United States, ⁸Pediatrics and Radiology, Keck School of Medicine of USC, Los Angeles, CA, United States

Synopsis

Keywords: Gray Matter, Quantitative Susceptibility mapping, Iron deposition, iron deficiency anemia, basal ganglia, QSM, iron susceptibility, iron regulation

Motivation: Women with iron deficiency anemia (IDA) have significant cognitive and sensorimotor deficits proportional to body iron bioavailability.

Goal(s): To identify changes in brain iron distribution in female IDA patients.

Approach: We measured iron susceptibility in 35 female IDA patients and 19 healthy controls (CNT) using quantitative susceptibility mapping (QSM).

Results: Systematic increases and decreases in iron deposition were seen between IDA and CNT subjects across the bilateral thalami, left putamen, left caudate, left nucleus accumbens, bilateral hippocampi, and bilateral amygdalae. Iron deficiency severity correlated with these findings.

Impact: This is the first study to demonstrate abnormal brain iron deposition in IDA patients, proportional to IDA severity. Brain iron deposition may provide pathophysiological insight into cognitive dysfunction and serve as an imaging biomarker to guide iron replacement strategies.

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