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Abstract #4892

DISTRIBUTION OF PARAMAGNETIC IONS IN EX-VIVO HUMAN BRAIN SAMPLES USING ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY

Jose Henrique Monteiro de Azevedo1,2, Fábio Seiji Otsuka3, Roberta Diehl Rodriguez4, Andre Avanzine2, Vanessa Souza5, Fernando Jr5, Maria Concepcion Garcia Otaduy3, and Carlos Ernesto Garrido Salmon2,6
1Graduate Program in Neurology, FMRP, University of São Paulo, Ribeirão Preto, Brazil, 2InBrain Lab, FFCLRP, University of São Paulo, Ribeirão Preto, Brazil, 3LIM44, Instituto de Radiologia, HC-FMUSP, USP, São Paulo, Brazil, 4Behavioral and Cognitive Neurology Group, Department of Neurology, FMUSP, São Paulo, Brazil, 5Department of Clinical Analyses, Toxicology and Food Sciences, FCFRP-USP, Ribeirão Preto, Brazil, 6Department of Medical Imaging, Hematology and Clinical Oncology , FMRP-USP, Ribeirão Preto, Brazil

Synopsis

Keywords: Gray Matter, Electron Paramagnetic Resonance

Motivation: Maintaining balanced metal levels is critical for brain function. Dysregulation may play a role in neurodegenerative disease development, but the mechanisms of metal regulation and distribution are still not fully understood.

Goal(s): To examine the interaction and distribution of iron and copper in the brain using Electron Paramagnetic Resonance (EPR), identifying regional and individual patterns of these metal ions.

Approach: EPR analyses were performed on ex-vivo brain samples from 19 subjects, examining nine brain regions of both brain hemispheres.

Results: EPR revealed clusters of iron and copper concentration patterns, where lower iron levels corresponded with higher copper levels in specific regions.

Impact: This research suggests that copper-iron balance in the brain could serve as an indicator of healthy metal regulation, with implications for neurodegenerative disease research and in vivo brain metal monitoring.

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