Keywords: Parkinson's Disease, Parkinson's Disease, Glymphatic system；DTI-ALPS
Motivation: Uncertain role of glymphatic system in pPD and its effect on PD transition.
Goal(s): Study aims to evaluate glymphatic system changes and PD conversion link in pPD group.
Approach: The study evaluated glymphatic function in pPD, new PD, and controls, and assessed the DTI-ALPS index's predictive power for PD conversion risk in pPD participants.
Results: pPD and ndPD groups had lower DTI-ALPS index than HC. pPD participants converted to PD, with risk inversely linked to theDTI-ALPS index.
Impact: The DTI-ALPS index indicates glymphatic dysfunction in pPD and predicts conversion to PD, aiding early risk assessment and intervention.
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