Meeting Banner
Abstract #4898

Susceptibility separation technique for assessing differences in the deep gray matter nuclei among parkinsonian disorders

Gaiying Li1, Hefan Zhou1, Changyuan Xu2, Haodong Zhong1, Weibo Chen3, Guangbin Wang4, and Jianqi Li1
1School of Physics and Electronic Science, East China Normal University, Shanghai, China, 2Central Hospital Affiliated to Shandong First Medical University, Shandong, China, 3Philips Healthcare, Shanghai, China, 4Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, China

Synopsis

Keywords: Parkinson's Disease, Quantitative Susceptibility mapping

Motivation: The clinically distinguish between PD, MSA and PSP is still challenging. Recently, susceptibility separation technique is proposed to hallmark myelin density and iron accumulation in the tissue.

Goal(s): To assess the myelin density and iron accumulation in the deep gray matter nuclei on clinical 3T MRI for the differential diagnosis of parkinsonian disorders.

Approach: We assessed 30 early PD, 31 early MSA patients, 22 early PSP patients, and 31 healthy controls using susceptibility separation method.

Results: We investigated the potential of iron and myelin from QSM separation method for the differential diagnosis of parkinsonian disorders. Iron deposition mainly observed in the midbrain nuclei.

Impact: The susceptibility separation method on QSM images delivers valuable and comprehensive insights into the iron deposition and myelin density among PD, MSA, and PSP. This may expand our understanding of susceptibility alternation in parkinsonian disorders.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords