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Abstract #4901

Changes to voxel-wise spontaneous activity and linked brain functional networks in PD patients with distinct motor subtypes.

Miaoran Guo1, Yueluan Jiang2, and Guoguang Fan3
1The First Affiliated Hospital of China Medical University., Shenyang, China, 2MR Research Collaboration Team, Siemens Healthineers Ltd., Beijing, China, 3The First Hospital of China Medical University., Shenyang, China

Synopsis

Keywords: Parkinson's Disease, fMRI (resting state), PD motor subtypes

Motivation: Clinical symptoms vary among motor subtypes of Parkinson’s disease (PD).

Goal(s): This study investigated brain functional differentiation and integration abnormalities across PD motor subtypes.

Approach: We used degree centrality (DC) and seed-based functional connectivity (FC) analyses, as well as voxel based morphometry (VBM) to explore neuroimaging manifestations associated with different PD motor subtypes.

Results: Postural instability and gait difficulty-dominant PD (PD-PIGD) patients showed reduced DC in the right superior frontal gyrus. Secondary FC alterations and gray matter volume atrophy also were more pronounced in PD-PIGD than in tremor-dominant PD.

Impact: These findings suggest that PD-PIGD represents a more severe PD subtype, offering new insights into clinical differences between PD motor subtypes.

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