Abstract #4907

GABAergic Imbalance in REM sleep behavior disorder in patients with Parkinson’s disease

Youmin Zhang^1,2, Naying He¹, Peng Wu³, JinYuan Weng³, Qiurong Yu^1,2, and Fuhua Yan^1,2

¹Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ²College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Philips Healthcare, Shanghai, China, Shanghai, China

Synopsis

Keywords: Parkinson's Disease, Spectroscopy

Motivation: There is a bidirectional relationship between Parkinson’s disease (PD) and Rapid eye movement (REM) sleep behavior disorder (RBD), however, the underlying mechanisms behind this relationship require further elucidation.

Goal(s): Try to achieve the stratification of PD patients with and without RBD.

Approach: Taking advantage of proton magnetic resonance spectroscopy (1H-MRS) with MEscher-Garwood Point RESolved Spectroscopy (MEGA-PRESS) to detect GABA+ levels in the left striatum.

Results: An intriguing phenomenon was found that GABA+ level increased in the left striatum in PD patients without RBD, but decreased in PD patients with RBD.

Impact: GABA+ level imbalance in PD patients with and without RBD might bring forward new layered diagnoses or therapeutic options.

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