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Abstract #4914

Investigation of water molecule metabolism in in vivo and ex vivo models using time-dependent diffusion MRI with long diffusion times

Ayane Ishida1, Junichi Hata1,2, Hinako Oshiro1, Chino Kawai1, and Hideyuki Okano2
1Tokyo Metropolitan University Graduate School, Tokyo, Japan, 2RIKEN Center for Brain Science, Saitama, Japan

Synopsis

Keywords: Preclinical Image Analysis, preclinical image analysis

Motivation: The metabolic function of water molecules in the brain can be used for understanding the pathogenesis of many neurological diseases and for the development of new drugs; however, it is not yet elucidated.

Goal(s): Our goal was to elucidate water dynamics using non-invasive time-dependent diffusion magnetic resonance imaging (td-DWI).

Approach: Three-dimensional diffusion-weighted imaging was performed to evaluate signal changes in in vivo and ex vivo models under the same brain temperature conditions.

Results: The difference in the signal change between the two models indicates that td-DWI can be used to observe the metabolic function of water molecules.

Impact: The ability to evaluate signal changes using noninvasive td-DWI with the same temperature settings for in vivo and ex vivo models suggest a new tool for elucidating the metabolic functions of water molecules.

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Keywords