Keywords: Small Animals, Preclinical, Obesity
Motivation: Obesity is a prevalent pathology that has a negative impact on human health. The cerebral changes that underly its development and treatment are under current investigation, and could be key in determining the fate of this disease.
Goal(s): To reveal the mouse brain changes underlying obesity development and treatment.
Approach: In vivo MRI and ex vivo immunofluorescence of the brain of obese or lean animals, before and after treatment with celastrol, a pre-clinical compound that induces body weight loss.
Results: In vivo diffusion tensor parameters and ex vivo markers of microglisis and astrocytosis consistent with obesity-induced neuroinflammation that are reversed with celastrol.
Impact: The standardization of MRI techniques that could reveal the brain changes underlying obesity development and treatment could boost the development of improved anti-obesity drugs and the understanding of its action mechanisms.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords