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Abstract #4916

Cerebral magnetic resonance imaging and immunofluorescence reveal the anti-inflammatory effects of an obesity treatment in mice

Adriana Ferreiro1, Maya Holgado1, Irene González-Villena2, Sara Gonzalez-Soto3, Lidia M Fernández-Sevilla4, Angeles Vicente3, Pilar Lopez-Larrubia1, and Blanca Lizarbe1
1Instituto de Investigaciones Biomédicas Sols-Morreale (CSIC-UAM), Madrid, Spain, 2Universidad Autónoma de Madrid, Madrid, Spain, 3Cell Biology, Faculty of Medicine, Universidad Complutense de Madrid, Madrid, Spain, 4Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcón, Spain

Synopsis

Keywords: Small Animals, Preclinical, Obesity

Motivation: Obesity is a prevalent pathology that has a negative impact on human health. The cerebral changes that underly its development and treatment are under current investigation, and could be key in determining the fate of this disease.

Goal(s): To reveal the mouse brain changes underlying obesity development and treatment.

Approach: In vivo MRI and ex vivo immunofluorescence of the brain of obese or lean animals, before and after treatment with celastrol, a pre-clinical compound that induces body weight loss.

Results: In vivo diffusion tensor parameters and ex vivo markers of microglisis and astrocytosis consistent with obesity-induced neuroinflammation that are reversed with celastrol.

Impact: The standardization of MRI techniques that could reveal the brain changes underlying obesity development and treatment could boost the development of improved anti-obesity drugs and the understanding of its action mechanisms.

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