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Abstract #4920

1H MR spectroscopy to evaluate the effects of lonidamine and temozolomide treatment in a mouse model of glioblastoma

Tareq Hamad H Alrashidi1, Sourav Bhaduri2, Elisabeth Non Gash1, Mohesh Moothanchery1, Christopher Ball1, Stephen Pickup3, Mahon Maguire1, and Harish Poptani1
1University of Liverpool, Liverpool, United Kingdom, 2Institute for Advancing Intelligence (IAI), TCG CREST, Kolkata, India, 3Department of Radiology, University of Pennsylvania, pensylvannia, PA, United States

Synopsis

Keywords: Small Animals, High-Field MRI, temozolomide , Glycolysis inhibitor, GBM

Motivation: To develop an alternate effective therapy for treating glioblastomas.

Goal(s): To assess metabolic changes as therapeutic indices of treatment response to Lonidamine (LND)and temozolomide (TMZ) against glioblastoma (GBM).

Approach: C57BL6 mice implanted with GL261 GBM cells were treated with saline or LND+TMZ. Metabolic changes were monitored using longitudinal MRS.

Results: Significant reductions in lactate, tCho/NAA, Lip+Lac/tCr and mI/tCr ratios, were observed post-treatment, suggesting early indicators of treatment response.

Impact: This combination therapy might be a suitable alternative for better treatment of glioblastomas.

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