Keywords: Preclinical Image Analysis, Spectroscopy, APP/PS1 mice, Astrocytes, Sex-difference
Motivation: Identifying pre-diagnostic biomarkers is crucial in the context of Alzheimer’s disease (AD).
Goal(s): We aimed to assess the predictive capability of magnetic resonance spectroscopy (MRS) in identifying early stages of AD.
Approach: MRS was conducted on the brainstem of both male and female APP/PS1 mice, with the results validated histopathologically and further corroborated through behavioral experiments.
Results: MRS revealed altered astrocyte metabolism in the brainstem of female APP/PS1 mice, but not in males. Our findings highlight the predictive potential of brainstem MRS as an early biomarker for detecting sex-specific onset of pathological changes in AD.
Impact: Including brainstem MRS results in routine clinical evaluations could allow clinicians to offer tailored lifestyle advice or enroll individuals in prevention trials focused on maintaining brain health.
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