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Abstract #4926

Serum metabolic changes in acute myelogenous leukemia during initial chemotherapy and their prognostic implications

Rong Hu1, Dandan Li1, Xiaofan Jia1, Yating Zhang1, Chengjie Chen1, Siwen Deng1, Yue Duan1, Haishan Yi1, Yingping Cao2, Jingxi Zhang2, Pengfei Guo3, and Yang Chen1
1Department of Laboratory Medicine, Fujian Medical University, Fuzhou, China, 2Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, China, 3Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, China

Synopsis

Keywords: Cancer, Metabolism, acute myeloid leukemia, serum

Motivation: Acute myeloid leukemia is marked by complex metabolic adaptations. Identifying metabolic alterations in patients may provide insights into treatment responses.

Goal(s): The study aims to explore serum metabolic profiles of newly diagnosed AML patients throughout their initial chemotherapy stages to find potential biomarkers for early drug resistance detection or prognostic predictions.

Approach: Using NMR serum metabolomics, serum samples were analyzed from AML patients at different chemotherapy stages. Multivariate statistical analysis, including PCA and OPLS-DA, were employed to detect metabolic differences.

Results: Distinct serum metabolic profiles were observed across first chemotherapy stages, primarily including various amino acid metabolism and lipid metabolism.

Impact: This study reveals serum metabolic changes in new AML patients during chemotherapy. It identifies distinct metabolic profiles, paving the way for early biomarkers of drug resistance and prognosis. Understanding these mechanisms can enhance treatment strategies and improve patient prognosis.

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