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Abstract #4929

Dynamic assessment of renal function by using endogenous CEST MRI in a reversible unilateral ureter obstruction rat model

Yalin Wu1, Haoran Sun1, Junping Wang1, Xiaoxiao Zhang2, Yizhong Yuan1, Yujing He1, Qiong Li1, Jiahui Zhang1, and Fangshi Zhao1
1Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China, 2MSC Clinical&Technical Solutions, Philips Healthcare, Beijing, China

Synopsis

Keywords: Kidney, Contrast Mechanisms

Motivation: Reversal of ureter obstruction can prevent renal fibrosis outcome.

Goal(s): In this study, we employed endogenous chemical exchange saturation transfer(CEST) MRI technique to assess dynamic renal function changes in reversible unilateral ureter obstruction (RUUO) rat model.

Approach: The CEST effect changes of multiple protons at different B1 strengths (1 and 2μT) were analyzed.

Results: Our results showed CEST MRI could demonstrate the progress and relief of obstructive nephropathy. The hydroxyl was the most sensitive proton before and after relief of ureter obstruction, while the amide changed slowly after relief at 1μT strength in renal cortex and outer medulla.

Impact: Endogenous CEST MRI could serve as a potential biomaker to evaluate the early renal fibrosis process induced by reversible unilateral ureter obstruction (RUUO). Different patterns of CEST effects in multiple protons possibly reflect various potential metabolic mechanisms.

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