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Abstract #4936

Assessing the relationship between glutamate, GABA, and synaptic density in healthy subjects after ketamine administration

Catarina Rua1, Claudio Agnorelli2, Kirran Ahmad2, Joseph Peill2, Gabriela Sawicka2, Matt Wall1, Paul Matthews2, Eugenii A. Rabiner1, David Nutt2, and David Erritzoe2
1Perceptive, London, United Kingdom, 2Imperial College London, London, United Kingdom

Synopsis

Keywords: Pharmacology, Drug Development

Motivation: Confounding literature on the effects of ketamine on the glutamatergic and GABAergic mechanisms related to synaptogenesis.

Goal(s): Measuring the relationship between glutamate, GABA and synaptic density in healthy subjects after ketamine administration.

Approach: We perform simultaneous PET and single-voxel MR spectroscopy acquisition in healthy volunteers before and after a ketamine dose.

Results: We report significant increased glutamate levels up to a week after ketamine dose, but no GABA trends. Trends toward increase in the PET synaptic marker, showing no association with glutamate levels.

Impact: This study investigates the link between Glutamate and GABA levels, measured by 1H MRS, and synaptic density, measured by [11C]UCB-J PET, in healthy individuals within a week after ketamine administration, exploring neuroplasticity effects.

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Keywords