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Abstract #4940

The combination of MR neurography at 3T and 7T for the assessment of nerve damage in peripheral neuropathies

Johann Malte Enno Jende1, Ke Zhang2, Christoph Matthias Mooshage3, Tanja Platt4, Volker Sturm5, Christian Jan Oliver Neelsen1, Julia Oppold1, Martin Bendszus3, Heinz Peter Schlemmer1, Mark E Ladd4, and Felix Tobias Kurz6
1Radiology, German Cancer Research Center, Heidelberg, Germany, 2Radiology, Heidelberg University Hospital, Heidelberg, Germany, 3Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, 4Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 5Medical Physics, Heidelberg University Hospital, Heidelberg, Germany, 6Neuroradiology, Hôpitaux Universitaires de Genève, Geneva, Switzerland

Synopsis

Keywords: Peripheral Nerves, Nerves, MR neurography

Motivation: To assess the size of proximal nerve fascicles in patients with polyneuropathies and to determine whether fascicle size has an impact on nerve structure and function

Goal(s): To visualize nerve fascicles at high resolution and to determine the impact of fascicle size on quantitative MR parameters.

Approach: Combination of high resolution T2-weighted imaging at 7T and quantitative (DTI, T2R) imaging at 3T in 10 polyneuropathy patients and 10 controls.

Results: Nerve fascicles were larger in patients compared to controls. There was a negative correlation between fascicular diameter and number of fascicles. The fascicular diameter correlated negatively with fractional anisotropy and positively with T2.

Impact: The results indicate that polyneuropathies are associated with a fusion of nerve fascicles which results in an increase in fascicular diameter and a reduced number of fascicles. This is related to a decline in quantitative parameters that codify nerve function.

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