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Abstract #4948

Neuroanatomical Signatures of Fluctuation Amplitude and Statistical Bias in Resting-State fMRI

Joonas A Autio1 and Takuya Hayashi1
1Center for Biosystems Dynamics Research, RIKEN, Kobe, Japan

Synopsis

Keywords: Neurotransmission, fMRI (resting state)

Motivation: Functional MRI (fMRI) is widely used to assess neural activity, yet the effects of diverse cortical input-output architectures on hemodynamic responses remain poorly understood.

Goal(s): To investigate how cortical input-output structures relate to fMRI fluctuation amplitude.

Approach: We combine cerebral blood volume-weighted (CBVw) fMRI in awake macaques with in vitro neuron density and receptor autoradiography data.

Results: Neuron density positively correlates with fMRI amplitude, while regions with higher receptor density show reduced local and global fMRI fluctuations.

Impact: Clarifying how brain input-output structures affect fMRI amplitude is crucial for advancing image processing and improving the interpretation of functional connectivity metrics.

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