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Abstract #4953

The Efficacy of Three-Dimensional Magnetic Resonance Elastography in Predicting Intraocular Pressure

Gai Zheng1, Shi Yu1, and Guan Haonan2
1Shengjing Hospital, China Medical University, Shenyang, China, 2GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: Head & Neck/ENT, Elastography

Motivation: Traditional intraocular pressure (IOP) measurements have limitations, including potential discomfort and susceptibility to ocular parameters.

Goal(s): The shear stiffness might be highly associated with IOP, and 3D-MRE could have the potential to provide a quantitative, noninvasive way to predict IOP independent of ocular parameters.

Approach: Volunteers were recruited to undergo 3D-MRE, GAT, NCT, and ocular parameter measurement. Multivariate linear regression and Spearman correlation analysis were used to assess the association between stiffness and IOPs and ocular parameters.

Results: Anterior chamber stiffness at 90 Hz showed a strong correlation with IOPGAT, independent of CCT and corneal curvature.

Impact: 3D-MRE provides a simple and non-invasive clinical method for IOP prediction independent of CCT and corneal curvature, and may be used to serve glaucoma patients and people undergone corneal surgery, etc.

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