Keywords: Other Musculoskeletal, biomarkers
Motivation: Lymphedema is a chronic progressive disease with no curative therapies. MR lymphangiography has potential to detect lymphatic congestion and characterize fundamental properties of lymphatic fluid flow noninvasively to inform therapeutic strategies.
Goal(s): Utilize non-invasive MR lymphangiography (MRL) to assess lymphatic fluid congestion quantitatively in lower-extremity lymphedema.
Approach: We assessed adults with lower-extremity lymphedema, gynecologic (GYN) cancer, and healthy participants using noninvasive 3.0T MRL.
Results: Patients with lymphedema show significantly elevated vessel/tissue signal compared to those with GYN-cancer and healthy controls, which increases with disease severity. Velocity-suppressed DANTE-prepared MRL signal is less suppressed in patients with lymphedema, indicating slower flow velocity.
Impact: Noninvasive MR lymphangiography can be applied in clinically-feasible scan time, and may provide useful imaging biomarkers in assessing severity of edema in lymphedema and lymphatic functioning, which could be used to more deeply characterize lymphedema development and novel therapies.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords