Keywords: Muscle, Muscle
Motivation: T2, water and PDFF may serve as early biomarkers for CKD-related ‘uremic’ myopathy, monitoring muscle inflammation and fat infiltration to aid in prognosis and early intervention.
Goal(s): This preliminary cross-sectional study examines associations between muscle MRI markers and clinical markers of kidney function and disease severity.
Approach: T2,water was obtained using a bi-exponential fit to multi-echo spin-echo images. PDFF was obtained using Dixon images. Pearson correlations were assessed from eleven subjects.
Results: T2, water exhibited a weak negative association with eGFR and a positive association with ECW fraction, suggesting inflammation and muscle volume overload in CKD may be monitored by T2, water.
Impact: Validating T2, water and PDFF as biomarkers for CKD-related myopathy could enable earlier detection and targeted intervention, potentially reducing the risk of adverse cardiovascular outcomes and improving patient prognosis.
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