Abstract #4981

High-temporal-resolution dynamic EPI at 9.4T for monitoring renal oxygenation in rats: Responses to hyperoxia and hypoxia

Songsong Sun^1,2, Kaixuan Zhao^3,4,5, Quan Tao^2,6, Qiugen Hu⁷, and Yanqiu Feng^1,2,6,7

¹School of Biomedical Engineering, Southern Medical University, Guangzhou, China, ²Guangdong Provincial Key Laboratory of Medical Image Processing & Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China, ³Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China, ⁴Department of Radiology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China, ⁵Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China, ⁶Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, China, ⁷Department of Radiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, China

Synopsis

Keywords: Kidney, Oxygenation, EPI

Motivation: Rapid and dynamic MRI is essential to capture changes in the renal blood oxygen system during stepwise oxygen stimulation.

Goal(s): In order to monitor the renal oxygenation various with high-temporal-resolution dynamic imaging by echo planar imaging (EPI) readout.

Approach: The dynamic EPI with a 1-second temporal resolution was used to monitor the T2*-weighted signal of the rat kidney under hypoxic and hyperoxic stimulation, applying a second-order system step response model to fit the T2*-weighted signal intensity-time curves.

Results: Dynamic EPI has higher temporal resolution and higher model parameter maps quality at the same image resolution.

Impact: Dynamic EPI can effectively monitor the changes of renal oxygenation and may be beneficial for renal injury detection.

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