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Abstract #4984

Enhancing the Diagnostic Accuracy of Amyloid PET: The Impact of MR-Guided PET Reconstruction

Mehdi Khalighi1, Christina B Young1, Skylar Weiss1, Michael Zeineh1, Guido A Davidzon1, Elizabeth Mormino1, and Greg Zaharchuk1
1Stanford University, Stanford, CA, United States

Synopsis

Keywords: PET/MR, PET/MR, Reconstruction, MR Priors

Motivation: Uptake in the supratentorial cortex is indicative of amyloid positivity. Due to PET's low spatial resolution and image noise, there can be inconsistencies in ratings among trained readers.

Goal(s): To investigate whether PET reconstruction with MR priors can improve the consistency of amyloid PET scan readings among trained readers.

Approach: A set of 106 18F-florbetaben (amyloid) PET/MRI exams were reconstructed using both conventional PET reconstruction and PET reconstruction with MR priors. These reconstructed images were then rated by 3 trained readers.

Results: Fifty percent of cases were rated inconsistently with conventional PET reconstruction. This number decreased to 19% with reconstruction using MR priors.

Impact: Given how common inconsistent ratings are for amyloid-PET, methods that improve the ability to distinguish intermediate amyloid levels may be valuable for the widespread use of this modality.

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