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Abstract #4986

High-resolution highly-accelerated free breathing 3D joint T1/T2 and fat fraction mapping of the liver at 0.55T

Felipe Ercoli1, Dongyue Si2, Michael Crabb2, Nicolás Garrido1,2,3, Karl Kunze4, Claudia Prieto1,2,5, and René Botnar1,2,3,5
1Millennium Institute for Intelligent Healthcare Engineering (iHEALTH), Pontificia Universidad Católica de Chile, Santiago, Chile, 2School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 3Institute of Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 4MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 5School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile

Synopsis

Keywords: Quantitative Imaging, Liver

Motivation: Quantitative MRI at low-field offers an affordable, accessible, non-invasive alternative to characterize liver tissue by correlating tissue parameters with liver disease stages.

Goal(s): To enable high-resolution 3D joint T1/T2 and fat-fraction liver mapping at 0.55T in clinically feasible scan times.

Approach: A Dixon GRE sequence with three interleaved 3D volumes preceded by preparation pulses for T1/T2 encoding was optimized for liver. Motion-corrected reconstruction with image-navigators and 4-fold acceleration enables isotropic high-resolution liver scan in ~8 min.

Results: Good agreement for T1, T2 maps and slight underestimation for fat-fraction is observed in phantoms. In-vivo T1, T2 and fat-fraction maps show values comparable to literature.

Impact: High-resolution free breathing 3D joint T1/T2 and fat-fraction mapping of the entire liver is feasible in a single scan of 8 min at low-field and may enable more affordable and comprehensive assessment of liver disease.

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