Abstract #5032

Glymphatic System Alterations in Thyroid Eye Disease: Evidence from DTI-ALPS Analysis

Haiyang Zhang^1,2,3, Mengda Jiang⁴, Yuting Liu^1,2,3, Xin Ning Lee^1,2,3, Zilin Fang^1,2,3, Jipeng Li^1,2,3, Yinwei Li^1,2,3, Jing Sun^1,2,3, Xiaofeng Tao⁴, Xuefei Song^1,2,3, Huifang Zhou^1,2,3, and Xianqun Fan^1,2,3

¹Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ²Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China, Shanghai, China, ³Center for Basic Medical Research and Innovation in Visual System Diseases, Ministry of Education, Shanghai, China, Shanghai, China, ⁴Department of Radiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China

Synopsis

Keywords: Biomarkers, Diffusion Analysis and Visualization

Motivation: Thyroid eye disease (TED) patients show brain abnormalities with unclear mechanisms. Glymphatic system dysfunction, responsible for brain waste clearance, may contribute to these changes.

Goal(s): To assess glymphatic function differences across TED phases and their correlation with clinical features.

Approach: We analyzed data from 47 TED patients (20 active, 27 inactive) and 24 controls using diffusion tensor imaging along the perivascular space (DTI-ALPS) and performed correlation analyses with clinical features.

Results: TED patients, especially inactive ones, had significantly lower left ALPS values than controls. Lower ALPS values correlated with longer disease duration and larger lid aperture.

Impact: This study highlights the glymphatic system's potential role in TED-related brain changes, emphasizing the need for further exploration of its pathophysiological mechanisms. Future validation of these findings may open new avenues for understanding and managing neurological impacts in TED.

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