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Abstract #5037

Amide Proton Transfer-weighted MRI and DWI as Biomarkers for Predicting Tumor Grades in Head and Neck Squamous Cell Carcinoma

Haoran Wei1, Fan Yang1, Xiaoduo Yu1, Lizhi Xie2, and Meng Lin1
1Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China, Beijing, China, 2GE Healthcare, MR Research China, Beijing, 100176, China, Beijing, China

Synopsis

Keywords: fMRI Analysis, CEST / APT / NOE, Differential diagnosis

Motivation: Amide proton transfer-weighted (APTw) MRI and DWI are advanced functional MR technologies that provide microstructural information about tissues. The histopathological grade of HNSCC is typically determined through invasive biopsy. Accurate and non-invasive methods are needed.

Goal(s): To investigate the potential of APTw MRI and DWI for predicting the histopathological grade of HNSCC.

Approach: Tumor grade was confirmed through pathological confirmation. APTw and ADC values were evaluated and compared across tumors with different grades.

Results: Both APTw and ADC were found to be effective in predicting the histopathological grades. The diagnostic accuracy was enhanced when both parameters were combined.

Impact: APTw and ADC provide unique insights into tumor microenvironment. Incorporating these imaging modalities into clinical practice offers a non-invasive approach for tumor grading, which could enhance preoperative assessment and potentially improve patient management.

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