Abstract #5039

Quantification of Total White Matter Perivascular Space Volume: Follow-up in Dutch-type Cerebral Amyloid Angiopathy

Manon R. Schipper¹, Thijs W. van Harten¹, Arie-Tjerk Razoux-Schultz¹, Kanishk Kaushik², Lydiane Hirschler¹, Sabine Voigt^1,2, Ingeborg Rasing², Emma A. Koemans², Rosemarie van Dort², Reinier G.J. van der Zwet², Sanne E. Schriemer², Erik W. van Zwet³, Jeroen van der Grond¹, Mark A. van Buchem¹, Steven M. Greenberg⁴, Marieke J.H. Wermer^2,5, Matthias J.P. van Osch¹, Marianne A.A. van Walderveen¹, and Sanneke van Rooden¹

¹Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Neurology, Leiden University Medical Center, Leiden, Netherlands, ³Biostatistics, Leiden University Medical Center, Leiden, Netherlands, ⁴Neurology, Massachusetts General Hospital, Boston, MA, United States, ⁵Neurology, University Medical Center Groningen, Groningen, Netherlands

Synopsis

Keywords: Neurofluids, Neurofluids

Motivation: Most commonly used methods to assess enlarged perivascular spaces (PVS) are visual rating scales that exhibit a strong ceiling effect and are limited to a single slice, limiting the assessment of progression.

Goal(s): To develop and apply a method to quantitatively assess whole-brain PVS in Dutch-type Cerebral Amyloid Angiopathy (D-CAA).

Approach: We applied a semi-automatic method with an in-house developed tool to assess whole-brain PVS volume fraction (PVS_vf) over four-year follow-up.

Results: Significant baseline differences were observed. No group differences were seen between symptomatic, pre-symptomatic D-CAA and controls in PVS_vfover four years of follow-up.

Impact: Sensitive measurement of PVS-enlargement will increase our understanding of disease mechanisms and allow monitoring of disease progression. This is relevant for developing treatment strategies and especially for tracking the effectiveness of treatments.

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