Keywords: Other Neurodegeneration, Analysis/Processing
Motivation: Complex sodium MRI provides unique metabolic insights but suffers from inherently low SNR (signal-to-noise ratio). While MPPCA denoising has proven effective for magnitude images, its application to complex sodium MRI data, particularly preserving phase information, remains unexplored.
Goal(s): To optimize MPPCA denoising for complex sodium MRI by: (1) determining optimal component selection, (2) characterizing noise distributions, and (3) quantifying structural preservation.
Approach: Applied MPPCA with varied components to phase-corrected complex sodium MRI data from 35 subjects. Analyzed denoising performance using PSNR, SSIM, and residual characteristics.
Results: Achieved optimal denoising and residual analysis confirmed unbiased noise removal with approximately Gaussian distribution, maintaining anatomical integrity.
Impact: This comprehensive validation establishes MPPCA as a robust denoising method for complex sodium MRI, providing specific guidelines for component selection and quality metrics. The improved image quality enhances sodium MRI's potential for clinical applications in metabolic and neurological assessments.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords