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Abstract #5044

Oxygen-enhanced MRI of the brain using 3D VIBE and 3D MR fingerprinting

Yasutaka Fushimi1, Sachi Okuchi1, Akihiko Sakata1, Takayuki Yamamoto1, Sayo Otani1, Satoshi Nakajima1, Satoshi Ikeda1, Shuichi Ito1, Masaki Umehana1, Yongping Ma1, Shin Morooka1, Junpei Fujimoto1, Hirohiko Imai1, Yuta Urushibata2, and Yuji Nakamoto1
1Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Siemens Healthcare K. K., Tokyo, Japan

Synopsis

Keywords: Neurofluids, MR Fingerprinting/Synthetic MR, oxygen enhanced MRI

Motivation: Inhaled oxygen leads to T1 shortening of CSF relatively quickly due to dissolved oxygen (oxygen-enhanced MRI, OE-MRI). Since CSF clearance mainly consists of rapid periarterial component (intramural periarterial drainage, IPAD) and slow perivascular component (glymphatic system), we assumed OE-MRI can represent rapid drainage from the interstitial fluid (ISF) in the brain.

Goal(s): Our aim is to promote the adoption of OE-MRI by utilizing commonly employed sequence.

Approach: We used 3D dynamic VIBE imaging as OE-MRI, and we also conducted 3D MR fingerprinting (MRF) to validate OE-MRI effect quantitatively.

Results: 3D VIBE demonstrated rapid signal change in CSF, which was validated by 3D MRF.

Impact: Oxygen-enhanced MRI (OE-MRI) utilizing 3D volumetric interpolated breath-hold examination (3D VIBE) can indicate rapid drainage from interstitial fluid (ISF) into cerebrospinal fluid (CSF) via intramural periarterial drainage (IPAD) pathway.

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Keywords