Keywords: Psychiatric Disorders, Brain
Motivation: This study aimed to examine the relationship between iron levels in subcortical brain regions and the risk of psychiatric disorders.
Goal(s): Despite observational studies linking brain iron levels to psychiatric disorders, the exact causal relationship remains poorly understood.
Approach: Utilizing two-sample Mendelian Randomization analysis, this study investigates the causal associations between iron levels changes in 16 subcortical nuclei and eight major psychiatric disorders.
Results: Iron levels in the left substantia nigra showed a negative association with the risk of major depressive disorder. Conversely, iron levels in the left putamen were positively associated with the risk of autism spectrum disorders.
Impact: The observed bidirectional trends between subcortical iron levels and psychiatric disorders, indicating the importance of the underlying biomechanical interactions between brain iron regulation and these disorders.
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