Abstract #5049

Dynamic Observation of Neuroprotective Effect of rTMS on BBB in an Ischemic Stroke Rat Model using DCE-MRI combined with Immunofluorescence

Xiangyu Tang¹, Qiya Zhang², Weiyin Vivian Liu³, Haoyue Shao², Shuting Huang², Azzam Saeed², Chaoxu Liu⁴, Feng Guo⁵, Li Peng¹, and Wenzhen Zhu¹

¹Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ²Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, wuhan, China, ³MR Research, GE Healthcare, Beijing, China, ⁴Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, wuhan, China, ⁵Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, wuhan, China

Synopsis

Keywords: Stroke, DSC & DCE Perfusion, Ischemic stroke; rTMS; BBB; HIF-1α; MMPs

Motivation: Repetitive transcranial magnetic stimulation (rTMS) has been widely used in clinical rehabilitation for ischemic stroke. However, there was limited research on the impact of rTMS on blood-brain barrier (BBB).

Goal(s): This study investigated the effects of rTMS on BBB in ischemic stroke rats.

Approach: Eighty rats were divided into two groups: the rTMS group received 10Hz rTMS for 2 weeks, while the control group received no treatment. Neurological assessments, MRI scanning and immunofluorescence staining were performed at multiple time points: baseline, day 0.25, 3, 7 and 14.

Results: 2-week rTMS treatment reduced rK^trans of infarct lesions and infarct volume, while improving neurological outcomes.

Impact: This study demonstrates that rTMS can effectively reduce BBB permeability and infarct volume in ischemic stroke, suggesting a potential therapeutic approach to improve neurological outcomes by stabilizing the BBB.

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