Abstract #5053

Association between Hemodynamics and Plaque Distribution: Insights from 4D Flow Imaging of M1 Segment in Ischemic Stroke Patients

Lixin Liu¹, Peirong Jiang², Peng Wu³, Yunjing Xue², He Wang^1,4,5, and Zhensen Chen^1,5

¹Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China, ²Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, China, ³Philips Healthcare, Shanghai, China, ⁴Human Phenome Institute, Fudan University, Shanghai, China, ⁵Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China

Synopsis

Keywords: Stroke, Flow

Motivation: Intracranial atherosclerotic is an important cause of ischemic stroke. The relationship between hemodynamics and plaque distribution isn’t fully elucidated.

Goal(s): To investigate the association between plaque distribution and hemodynamics on different shapes of M1.

Approach: TAWSS and OSI were assessed with 4DFlow, while plaque with HR-VWI. Comparison of TAWSS, OSI and wall thickness between outer- and inner-wall of the curved-section of M1, and comparisons of hemodynamics between thick- and thin-wall on straight-section were performed.

Results: Regardless of M1 shape, plaques typically developed in regions of low WSS and high OSI. TAWSS_CV, OSI_CV and Wall thickness_CVare also associated with plaque development.

Impact: Our findings enhance understanding of hemodynamics effect on plaque development in intracranial atherosclerosis, and may provide guidance for risk assessment and treatment strategies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.