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Abstract #5062

Kidney-brain crosstalk: early assessment of brain damage in chronic kidney disease by using brain microcirculation impariment features

Xiaolin Guo1, Aoxue Mei1, Jianxun Qu2, Xin Lou1, and Jinhao Lyu1
1First Medical Center of Chinese PLA General Hospital, Beijing, China, 2Siemens Healthineers, Beijing, China

Synopsis

Keywords: Stroke, Neuro, Renal-brain axis; Cerebral microcirculation damage

Motivation: Chronic kidney disease (CKD) prevalence is rising worldwide, potentially impacting brain health via vascular pathways.

Goal(s): Compare brain damage across CKD severity levels, identify key imaging features, and provide early indicators.

Approach: Enrolled 80 CKD patients, gathered eGFR and MRI data, analyzed cerebral microcirculation features and correlated them with CKD severity using ANOVA and logistic regression.

Results: Severe CKD correlates with higher WMH scores; WMH identified as an independent predictor of brain damage in CKD patients.

Impact: WMH potentially serving as an early warning indicator of the severity of cerebral damage in kidney disease.

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Keywords