Abstract #5065

Hyperemia detection on dynamic susceptibility contrast versus arterial spin labeling MRI in stroke post-endovascular therapy

Carolyn A Lomahan ^1,2, Marie Luby ¹, Georgios Kalarakis ^2,3, Amie W Hsia ^1,4, John K Lynch ^1,5, Sana Somani ^1,4, Fabian Arnberg-Sandor ^2,3, and Lawrence L Latour ¹

¹Acute Cerebrovascular Diagnostics Unit, National Institutes of Health (NIH)/ National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD, United States, ²Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, ³Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden, ⁴Medstar Washington Hospital Center Comprehensive Stroke Center, Washington, DC, United States, ⁵Suburban Hospital - Johns Hopkins Medicine, Bethesda, MD, United States

Synopsis

Keywords: Stroke, Vascular, Hyperemia, cerebral blood flow

Motivation: Hyperemia, or increased relative cerebral blood flow (rCBF), is a potential sequalae following endovascular therapy (EVT) for large vessel occlusion stroke patients. Reliable hyperemia detection on 3T MRI post-EVT is warranted as it may have an impact on long term clinical outcomes.

Goal(s): Our goal was to evaluate hyperemia detection on two perfusion MRI sequences.

Approach: Hyperemia qualitative and quantitative assessments were compared on dynamic susceptibility contrast (DSC)-rCBF and arterial spin labeling (ASL)-rCBF in acute ischemic stroke patients at 24-hour and 5-day post-EVT.

Results: The findings suggest hyperemia is more conspicuous on ASL-rCBF than DSC-rCBF in stroke patients post-EVT.

Impact: Hyperemia detection by arterial spin labeling-relative cerebral blood flow compared to dynamic susceptibility contrast-relative cerebral blood flow may be more accurate in evaluating blood flow increases which can contribute to optimization of clinical care for stroke patients post-EVT.

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