Abstract #5067

Feasibility of multi-echo QSM to quantify cortical iron depositions hindering cognitive improvement in patients after carotid endarterectomy

Masahiro Yabuki¹, Yosuke Akamatsu¹, Ikuko Uwano², Futoshi Mori², Makoto Sasaki², Kunihiro Yoshioka³, Kohei Chida¹, Masakazu Kobayashi¹, Shunrou Fujiwara⁴, and Kuniaki Ogasawara¹

¹Department of Neurosurgery, School of Medicine,Iwate Medical University, Yahaba, Japan., Iwate prefecture, Japan, ²Division of Ultrahigh Field MRI, Institute for Biomedical Sciences,Iwate Medical University, Yahaba, Japan., Iwate prefecture, Japan, ³Department of Radiology, School of Medicine, Iwate Medical University, Yahaba, Japan., Iwate prefecture, Japan, ⁴Division of Molecular and Cellular Pharmacology, Department of Pathophysiology and Pharmacology, School of Pharmaceutical Science, Iwate Medical University, Yahaba, Japan., Iwate prefecture, Japan

Synopsis

Keywords: Stroke, Quantitative Susceptibility mapping

Motivation: To clarify whether cortical magnetic susceptibility indicating iron deposition can affect cognitive improvement after revascularization to chronic ischemic patients.

Goal(s): To determine whether preoperative cortical magnetic susceptibility quantified by QSM and changes in postoperative CBF are statistically associated with cognitive improvement after CEA.

Approach: Preoperative QSM, pre- and post-operative brain perfusion SPECT and neuropsychological assessments are performed in patients undergoing CEA. After image normalization, magnetic susceptibility values and CBF were measured using the ROI templates.

Results: Preoperative cortical magnetic susceptibility as well as postoperative changes in CBF are associated with cognitive improvement after CEA.

Impact: The present study demonstrated that preoperative high cortical magnetic susceptibility adversely affects cognitive improvement after CEA and that preoperative QSM predicts patients who will not experience cognitive improvement after CEA.

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