Keywords: Other Neurodegeneration, biomarkers
Motivation: Neuropsychiatric systemic lupus erythematosus (NPSLE) is challenging to diagnose owing to its diverse clinical manifestations, which overlap with systemic lupus erythematosus (SLE) complications.
Goal(s): We aimed to use mean apparent propagator MRI (MAP-MRI) to investigate white matter microstructural changes in patients with NPSLE to identify biomarkers for diagnosing the disease.
Approach: We compared MAP-MRI metrics between patients with NPSLE and SLE.
Results: Return-to-origin probability and return-to-axis probability were significantly decreased in multiple brain regions in patients with NPSLE. MAP-MRI showed sensitivity for detecting white matter pathology in NPSLE.
Impact: Application of mean apparent propagator MRI for patients with neuropsychiatric systemic lupus erythematosus may help identify early biomarkers of the disease, which is crucial for timely intervention and treatment strategies.
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